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In specific, cytisine is missing from current evaluations,14,15 of smoking cessation drugs. This study evaluates the literature on the efficacy of cytisine for smoking cessation and conducts a meta-analysis of placebo-controlled trials. Search and selection of studies All studies of the result of cytisine on smoking cigarettes cessation were browsed, in any language.

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com, and Scholar. google.com were reviewed, using the keywords cytisine, cytisin, zytisin, cytisinum, Tabex, and smoking cigarettes cessation. The maker of Tabex (Sopharma, Sofia, Bulgaria) was contacted and provided scientific posts and reports on Tabex in a number of languages. Tobacco reliance specialists in Bulgaria, the Czech Republic, Germany, Poland, and Russia were contacted, and the recommendation lists of the retrieved short articles were consulted.

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The original articles and their translations are readily available at http://www. stop-tabac. ch/cytisine. Placebo-controlled trials were consisted of in a meta-analysis. Because, to my knowledge, this is the very first review on this topic, outcomes of all the recovered studies are reported, managed and uncontrolled, despite the fact that uncontrolled studies have less clinical worth.

Cigarette smoking abstaining rates were computed utilizing as the denominator the total number of participants consisted of at the start of the trial, and individuals missing at follow-up were counted as cigarette smokers (intention-to-treat analysis), when these information were readily available. The cigarette smoking abstaining rates reported by the initial authors were used, even though most of the time, no accurate meaning of smoking cigarettes abstaining was provided.

Cytisine (baptitoxine, sophorine) smoking cessation drug, chemical  structure, Stock Photo, Picture And Low Budget Royalty Free ImagePic ESY-039850812 - agefotostock

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Results of the placebo-controlled trials were included in a meta-analysis. The I2 fact was used to assess heterogeneity; this fact describes the portion of irregularity due to true heterogeneity instead of error or chance. Since there was heterogeneity, a random-effects model was used to approximate the pooled weighted average of odds ratios (ORs) using computer software (Evaluation Manager, version 4.

Ten research studies were found, reported in 16 short articles,,18-32 that checked the result of cytisine on smoking cessation in 17 various samples of cigarette smokers. The Bulgarian drug Tabex was used in 9 of these research studies. Each tablet of Tabex contains 1. 5 mg of cytisine.  Check it Out  are swallowed, and the maker recommends using 6 tablets per day (total, 9 mg of cytisine) throughout the first 3 days after smoking cigarettes cessation, then reducing the dose slowly down to 2 tablets per day until the 25th day, when the treatment is stopped.